EBE-A22

??【編號】：126691

??【產(chǎn)品名稱】：EBE-A22

??【規(guī)格】：5MG

??【用途】：

　　EBE-A22

　　Product Name： EBE-A22

　　CAS號：229476-53-3

　　分子式：C17H16BrN3O2

　　分子量：374.23

　　貯存：儲存溫度-20°C

　　可溶性： 25°C： DMSO

　　生化和生理學(xué)機理：

　　Description：

　　EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive. The brominated anilinoquinazoline derivative PD153035 exhibits a very high affinity and selectivity for the epidermal growth factor receptor tyrosine kinase (EGF-R TK) and shows a remarkable cytotoxicity against several types of tumor cell lines. In contrast, its N-methyl derivative, designated EBE-A22, has no effect on EGF-R TK but maintains a high cytotoxic profile. The present study was performed to explore the possibility that PD153035 and its N-methyl analogue might interact with double-stranded DNA, which is a primary target for many conventional antitumor agents. We studied the strength and mode of binding to DNA of PD153035 and EBE-A22 by means of absorption, fluorescence, and circular and linear dichroism as well as by a relaxation assay using human DNA topoisomerases. The results of various optical and gel electrophoresis techniques co

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EBE-A22

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EBE-A22

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　　EBE-A22

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