PF-670462, ≥98%(HPLC)

??【編號(hào)】：127947

??【產(chǎn)品名稱(chēng)】：PF-670462, ≥98%(HPLC)

??【規(guī)格】：10MG

??【用途】：

　　PF-670462, ≥98%(HPLC)

　　Product Name： PF-670462

　　CAS號(hào)：950912-80-8

　　分子式：C19H20FN5·2HCl

　　分子量：410.32

　　貯存：儲(chǔ)存溫度-20°C

　　可溶性： DMSO 100 mM Water

　　生化和生理學(xué)機(jī)理：

　　PF-670462, a selective CK1 ε/δ inhibitor, causes a significant phase delay in animal models of circadian rhythm; it remains unclear whether one of the kinases has a predominant role in regulating the circadian clock. PF-670462 has been proved to be both a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations; in transfected whole cell assays, it caused a concentration-related redistribution of nuclear versus cytosolic PER. When tested in free-running animals, 50 mg/kg s.c. PF-670462 produced robust phase delays when dosed at circadian time (CT)9 (-1.97 ± 0.17 h). PF-670462 attenuates methamphetamine-stimulated locomotion in vivo.

上一篇：Zaurategrast，≥99％		下一篇：VTP-27999

PF-670462, ≥98%(HPLC)

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PF-670462, ≥98%(HPLC)

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　　PF-670462, ≥98%(HPLC)

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