Reversine, ≥98%(HPLC)

??【編號(hào)】：126916

??【產(chǎn)品名稱】：Reversine, ≥98%(HPLC)

??【規(guī)格】：5MG

??【用途】：

　　Reversine, ≥98%(HPLC)

　　Product Name： Reversine

　　CAS號(hào)：656820-32-5

　　分子式：C21H27N7O

　　分子量：393.49

　　介紹： Reversine

　　貯存：儲(chǔ)存溫度-20°C

　　可溶性： 25°C： DMSO

　　生化和生理學(xué)機(jī)理：

　　Description：

　　IC50 Value： 150 nM (Aurora Kinase A); 500 (Aurora Kinase B); 400 nM (Aurora Kinase C) [1]

　　Reversine, a small synthetic purine analogue (2,6-disubstituted purine), has been shown to be effective in tumor suppression. These effects of reversine are due to the inhibition of Aurora A and B.

　　in vitro： Reversine induced apoptosis in PDTC cells with caspase-3 and caspase-8 activation, but not caspase-9. Use of a pan-caspase inhibitor before treatment with reversine attenuated cell death [2]. Reversine significantly suppressed the proliferation of two OSCC cell lines (OC2 and OCSL) and markedly rendered cell cycle arrest at G2/M stage. Reversine also induced cell death via both caspase-dependent and -independent apoptosis. In addition,reversine could inhibit Akt/mTORC1 signaling pathway, accounting for its ability to induce autophagy [3]. Reversine pre-treatment, at very low concentration (50 nM), caused a marked increase in the differentiation yiel

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Reversine, ≥98%(HPLC)

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Reversine, ≥98%(HPLC)

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　　Reversine, ≥98%(HPLC)

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