噴昔洛韋，≥99％

??【編號(hào)】：125160

??【產(chǎn)品名稱】：噴昔洛韋，≥99％

??【規(guī)格】：50MG

??【用途】：

　　噴昔洛韋，≥99％

　　Product Name： Penciclovir

　　別名：6H-Purin-6-one, 2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-

　　CAS號(hào)：39809-25-1

　　分子式：C10H15N5O3

　　分子量：253.26

　　介紹： Penciclovir

　　貯存：儲(chǔ)存溫度-20°C

　　可溶性：

　　DMSO 34 mg/mL

　　Water 1 mg/mL

　　Ethanol <1 mg/mL

　　生化和生理學(xué)機(jī)理：

　　Description： IC50 Value： 2.3±0.8 mg/ml(EC50, inhibition EBV DNA synthesis); >100mg/ml(50% cell growth inhibitory concentration of both P3HR-1 and Raji cells) Penciclovir, a novel acyclic nucleoside analogue, has demonstrated efficacy against HSV types 1 and 2 and seems to have a pharmacological advantage due to a prolonged half-life of its active form in HSV-infected cells[1]. in vitro： Treatment with GCV or PCV induced rapid accumulation of cells in S-phase and apoptotic death, GCV (and to a lesser extent PCV) increased phosphatidyl serine translocation, induced positive TUNEL results with alterations in cell morphology, caused marked propidium iodide staining and induced DNA laddering. [2]. B-95-8 cells were treated with penciclovir or aciclovir at 1 and 10 ug/ml for 7 days, At 1 ug/ml, both compounds were inactive, but at 10 ug/ml, the virus yield relative to that of untreated virus controls was reduced by 94 and 86% by penciclovir and aciclovir, respectively[5]. in vivo： Penciclovir pharmacokinetics following oral administration of famciclovir were nonlinear within the dosage range studied, likely because of saturation of famciclovir metabolism[3]. Treatment with penciclovir (intravenous formulation) was associated with the development of resistant HSV in only one severely immunocompromised patient (day 7 isolate IC(50) = 2.01 microg/ml), although treatment was effective and resulted in the complete clearance of the lesion by day 8. No patients receiving topical penciclovir developed treatment-associated penciclovir-resistant HSV[4]. Clinical trial： A Comparative Study of the Efficacy of Penciclovir 10 mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore Sufferers. Phage4
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噴昔洛韋，≥99％

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噴昔洛韋，≥99％

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　　噴昔洛韋，≥99％

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