特立氟胺，≥99％

??【編號】：124990

??【產(chǎn)品名稱】：特立氟胺，≥99％

??【規(guī)格】：10MG

??【用途】：

　　特立氟胺，≥99％

　　Product Name： Teriflunomide

　　CAS號：163451-81-8

　　分子式：C12H9F3N2O2

　　分子量：270.21

　　貯存：儲存溫度-20°C

　　可溶性： DMSO

　　生化和生理學(xué)機理：

　　Teriflunomide (also known as A77 1726), the active metabolite of an approved antirheumatic drug Leflunomide, is an emerging oral therapy for multiple sclerosis (MS). Teriflunomide has demonstrated anti-inflammatory, antiproliferative and immunosuppressive effects. Teriflunomide is an immunomodulator with a unique mechanism of action. Although the mechanism of action for Teriflunomide is not fully understood, research supports that Teriflunomide inhibits the proliferation of stimulated T and B lymphocytes in the periphery thought to be responsible for the damaging inflammatory process in MS, while generally maintaining normal immune function. Teriflunomide selectively and reversibly inhibits DHODH, a key enzyme in de novo pyrimidine synthesis required by rapidly dividing lymphocytes. Through this effect, it limits the expansion of stimulated T- and B-cells in the periphery and diminishes the numbers of activated T- and B-cells available to migrate into the central nervous system (CNS). Because the salvage pathway for pyrimidine synthesis is not affected by Teriflunomide, resting lymphocytes maintain their viability and remain unaffected by Teriflunomide.

上一篇：SB705498, ≥99%		下一篇：替尼泊苷，≥98％

特立氟胺，≥99％

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特立氟胺，≥99％

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　　特立氟胺，≥99％

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