VcMMAE, ≥99%
| ??【編號】：125591 ??【產品名稱】：VcMMAE, ≥99% ??【規格】：1MG ??【用途】：   VcMMAE, ≥99%
Product Name： VcMMAE
CAS號：646502-53-6
分子式：C68H105N11O15
分子量：1316.63
貯存： 儲存溫度-20°C
可溶性： DMSO
生化和生理學機理：
VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc). Antibody-drug conjugates (ADCs) are designed to combine the exquisite specificity of antibodies to target tumor antigens with the cytotoxic potency of chemotherapeutic drugs. In vivo studies demonstrated that the peptide-linked conjugates induced regressions and cures of established tumor xenografts with therapeutic indices as high as 60-fold. These conjugates illustrate the importance of linker technology, drug potency and conjugation methodology in developing safe and efficacious mAb-drug conjugates for cancer therapy.
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